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This microvascular rarefaction is likely a key contributor to the reduced muscle endurance observed in IGF- 1R KD mice, as capillary networks are critical for sustaining aerobic metabolism and preventing muscle fatigue [58, 62, 63]
The results were compelling: the leucovorin group showed significantly greater gains in language scores compared to placebo, with a medium-to-large effect size (Cohens d 0.70)
doi: 10.1016/j.metabol.2021.154959 33 TurtonNCufflinNDewsburyMFitzpatrickOIslamRWatlerLLet al
This shift makes a calorie deficit more achievable without relying on willpower alone
